The greatest annoyance with my setup is when I accidentally press the backslash key. When this happens, XBMC loses focus making it so I cannot get back into full screen mode.
After some Googling I found this snippit that will disable the backslash shortcut and replace it with a stern warning:
$home/.xbmc/userdata/keymaps and add:
<keymap> <global> <keyboard> <backslash>Notification(Backslash, Don't press backslash, 3)</backslash> </keyboard> </global> </keymap>